This does not account for neutral site non-bowl games.
Riddick Stadium (NC State) 0-1-7 (.000)- Before the days of Carter-Finley Stadium, Riddick Stadium was the site of NC State football, and despite the Hokies having good fortune in the new building, the old venue was a place where Hokie dreams went to die, as the Wolfpack racked up seven wins in eight tries from 1924 to 1963 (I was surprised to find that the Hokies have played the Wolfpack the sixth-most times of any opponent throughout their history). Finally, and to no objection from any Hokies, the stadium closed in 1965 after a 58-year run and gave way to Carter-Finley.
Bryant-Denny Stadium 0-7 (.000), Legion Field 1-2 (.333) (Alabama, UAB)- Color me shocked that the Crimson Tide, perhaps the sport's most successful team, would have dominated the Hokies wherever they played (though the Hokies did claim their only win in the series in a rousing 38-7 victory in the 1998 Music City Bowl, which was a neutral site game, so it didn't end Tech's futility in the Heart of Dixie). Virginia Tech started playing 'Bama (as they're affectionately known throughout the college football world) in 1932, and lost three one-sided decisions at what was then just Denny Stadium. The series then took a two-game swing to Legion Field in Birmingham (with the lone Alabama visit to Lane Stadium sandwiched in between), which had the Hokies on the losing side of once again, pretty ridiculous margins. The series returned to Denny in 1972, where the Hokies lost two more by a landslide before the stadium was christened Bryant-Denny Stadium for the Hokies' final two visits, which they only lost by a combined score of 66-7. In the Hokies' only road game against University of Alabama Birmingham in 1998, they scorched the Blazers (I'm sorry, that was bad) 41-0 at what was their official home stadium, providing Tech with their only win at Legion Field.
Though Tech has played Alabama three times since, all three have been neutral site games, and the Tide ended their contract with the city of Birmingham in 2004 due to the disrepair of the venue. UAB, by comparison, still plays in the venue, or at least plans to as long as they successfully revive their football program in 2017 after now-embattled President Ray Watts made the head-case decision to end the football (and bowling and rifle) program(s) on the basis that it was hemorrhaging money (later a third-party accounting firm determined that the football program was ACTUALLY TURNING A SLIGHT PROFIT), thereby ending the athletic careers of all involved and destroying at least the football program for the next half decade. Despite Watts receiving votes of no confidence from a two-thirds majority of the UAB Faculty Senate and the UAB Alumni Society, demanding for his resignation, he has yet to do so.
Michie Stadium 0-5 (Army) (.000)- Michie Stadium was one of the first "houses of horror" for the Hokies. They played their first contest there in 1938 and took it on the chin 39-0. In fact, they've only scored 26 points in five games at the venue, though the last time they played there was in 1962. It is worth noting, however, that the Hokies have won ONE game in the series (in 1905), played at West Point in fact, though it pre-dated Michie Stadium and I am unable to find the official venue where the game was played.
FedEx Field 0-3 (.000) (USC, Boise State, Cincinnati)- If ever there were a stadium/game/set of games to boycott (for Hokie fans, but those who are Redskins fans should feel free to keep going to see their professional team play), it would be FedEx Field and those awful neutral site games that Jim Weaver scheduled and gave into ESPN to have re-scheduled. While I don't disagree with Weaver scheduling any of them on opponent alone (okay so maybe Cincinnati is a bit iffy), being that it's a "neutral" site game and intended to that he scourge
Sun Bowl Stadium 0-2 (.000)
Worden Field (Navy) 1-7 (.125)- The unofficially-official timeline of Worden Field on the internet cites that the venue was the site of Navy football from the "1890s through 1924," but to the Hokies, the horrors were never-ending, as all of Tech's seven losses in the series (they're 3-7 against the Midshipmen all-time) occurred there between 1904-1915. Tech's last to games against Navy were victories, both under Frank Beamer, in 1987 and 1995, the latter of which was in Annapolis, but at Navy-Marine Corps Memorial Stadium, which has been much kinder to the Hokies, who are 2-0 there (also winning the 2014 Military Bowl there against Cincinnati 33-17).
Scott Stadium 19-3-10, Madison Hall Field (1888-1912) 1-5 (.167), Lambeth Field (1913-1930) 2-2
Orange Bowl 2-9 (.182) (Dolphin Stadium, Land Shark Stadium, Sun Life Stadium, now Hard Rock Stadium 3-6 (.333) including Nebraska, Kansas, Stanford and Cincinnati Orange Bowl losses and win)
Heinz Field 1-4 (.200)
Commonwealth Stadium (Kentucky) 1-4 (.200)
Memphis Memorial Stadium (now Liberty Bowl Memorial Stadium) 1-4 (.200)
Carrier Dome 2-7 (.222)
Williams-Brice Stadium (South Carolina) 2-1-5 (.250)
Wilson Field (Washington & Lee) 2-1-5 (.250)- Granted the Hokies haven't played at this venue since 1952 (and that the venue has since been demolished and rebuilt on the same location it has sat for over 100 years, and with the same namesake no less), or faced the Generals at all since 1952. But for whatever reason, Wilson Field was always a tough place to play for the Hokies.
Doak Campbell Stadium 5-13 (.278)
Memorial Stadium (Clemson) 4-8 (.333)
Tulane Stadium 2-3 (.400), Louisiana Superdome (now Mercedes Benz Superdome Florida State, Auburn, Michigan and Nebraska Sugar Bowl losses and win) 2-4 (.333)
Milan Puskar Stadium 6-7 (.46) Mountaineer Field 3-8 (.273)